A team led by researchers at the University of Illinois in the United States extracted two phenolic substances, protocatechuic acid and gallic acid, from the outer shell of coffee beans and the "silver skin" that was shed after baking, and used these substances to treat the fat cells of mice. Macrophage and adipocytes in mice and related hormone changes, as well as the response of the inflammatory pathway.news world ahmed
Previous studies have found that people with severely overweight have a chronic inflammation of the abdominal adipose tissue, which is often thought to be one of the factors that cause changes in insulin levels, cause type 2 diabetes, and even increase the risk of cancer in obese people.
The study, recently published in the British Journal of Food and Chemical Toxicology, shows that when obesity-related inflammation occurs, macrophages interact with fat cells, mitochondria in fat cells decrease, fat burning ability decreases, and oxidative stress levels Increase, thereby interfering with glucose absorption, slowing down the rate of metabolism; while phenolic substances extracted from coffee bean shells can block this effect of macrophages on fat cells, keep fat burning, stimulate fat breakdown, and stimulate insulin The sensitivity of the pathway promotes glucose uptake and utilization and restores normal metabolism.news world ahmed
The researchers say the findings promise to provide new treatments for preventing type 2 diabetes and cardiovascular disease, as well as potential business opportunities for coffee bean shells.